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It is well-known that pro-inflammatory cytokines that induced chronic inflammatory response have to be considered as two potent activators of pro-oncogenic signaling that were linked to HCC onset 136 , such as IL-6 prevents DNA-damage-induced hepatocyte apoptosis through suppression of p53 and enhances -catenin activation 137

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Second, although the descriptive statistical analysis method used in this study provided a basic understanding of the approval status of DTx in the selected countries, it may not be sufficient to fully reflect the overall development trend of DTx worldwide